Can cause white poops through other item effects such as A Card Against Humanity or Re-Lax pills. You get a couple of seconds of invincibility to move away after, The main benefit of this Soul Stone is that it automatically activates if you die, meaning it is effectively an extra passive life while held, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Lazarus, Activates the D6 and D20 effects, rerolling all items and pickups in the room. Press question mark to learn the rest of the keyboard shortcuts. The game has no official release date, instead getting a release window of "Q3 2021" . At +0 Luck theres a ~2.5% chance for this effect to activate, The size of the rift scales with your tear damage, In Antibirth this item was called Oculus Rift, A familiar boil that randomly fires bursts of tears, similar to the Boil enemy. . * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, From the Sacred Heart to the Magic Mushroom and the mighty Brimstone, here are some of the best and strongest items available in The Binding Of Isaac. the ability to fly. Based on the Steam Workshop mod created by Amethyst, UNLOCK: Unlock this item by using 5 Gulp! with Lilith, After picking up 15 hearts, Isaac gains a permanent angelic familiar and a soul heart drops, Possible familiars include: Holy Water, Guardian Angel, Sworn Protector, The Relic and Seraphim, It is possible to get multiple followers by continuing to pick up hearts, at intervals of 15 hearts each, After all 5 familiars have spawned, it will just drop a soul heart every 15 hearts collected, UNLOCK: Unlock this item by beating Boss Rush with Lilith, Two items now spawn in each of your item rooms, however only one can be taken and the other will disappear, A crown that replaces normal tears with blue diamond tears while you don't have any empty red heart containers or bone hearts, While the effect is active, tears do double damage and have -0.30 Shot Speed, The crown will glow blue while active, if inactive it will appear grey, The effect will also deactivate for the rest of the current room when you take damage, regardless of your health, When a room clear would otherwise yield no rewards, it now spawns 1-3 pennies, REPENTANCE - Deep Pockets no longer adds a pill/card slot, instead increases money cap to 999, UNLOCK: Unlock this item by beating The Chest floor with Keeper, A flying familiar that bounces around the room with a damaging aura, dealing rapid damage to any enemies inside it and boosting Isaac's tear damage, While standing in the black aura, Isaac has a temporary 1.5x damage multiplier (this will stack if you have more than one Succubus), The aura deals 2.5 damage per tick or about 7.5 - 10 damage per second, UNLOCK: Unlock this item by beating The Lamb with Lilith, Gives you a different tear effect with every tear that you fire, Tear effects include: Anti-Gravity, Ball of Bandages (Lvl 4), Bumbo (Lvl 3), Continuum, Cupid's Arrow, Compound Fracture, Euthanasia, Explosivo, Eye of Greed, Fire Mind, Flat Stone, Flat Worm, God's Flesh, Godhead, Head of the Keeper, Holy Light, Hook Worm, Ipecac, Iron Bar, Jacob's Ladder, Knockout Drops, Lachryphagy, Little Horn, Lodestone, Mom's Contacts, Mom's Eyeshadow, Mom's Perfume, Mucormycosis, My Reflection, Mysterious Liquid, Ocular Rift, Ouija Board, Ouroboros Worm, The Parasite, Parasitoid, Polyphemus, Pop!, Proptosis, Pulse Worm, Ring Worm, Rotten Tomato, Rubber Cement, Serpent's Kiss, Sinus Infection, Spider Bite, Strange Attractor, Sulfuric Acid, Technology Zero, Tiny Planet, Trisagion and Wiggle Worm, With Dr. Fetus, this item will also cycle through random Bomb Modifiers (e.g. While you have this flame you also have that item's effect, The flame deals double your tear damage to any enemies that touch it, but if it takes too much damage the flame will disappear and you lose the item's effect, Wisps are randomly chosen from Item Room, Boss Room and Shop item pools, with a 25% chance to pick the same pool as the current room. * golden chest pool, gold chest pool, item room, treasure room, item room pool, green, ball, REPENTANCE - Brown Nugget flies now have faster shot speed, and their damage has been increased to 3.5 (from 2). It grows rapidly in size then explodes into a gas cloud that damages nearby enemies, When the explosion happens, more homing fungus tears fire out in random directions. After a few seconds, the crosshair will disappear, and the Ghost will do certain things based on what you targeted: Items, pickups, trinkets: Brings them to Isaac. 5 Boss Secrets That ALL Players Need To Know! Deflected tears turn into homing tears and fire back at enemies, dealing 2 damage. A familiar baby that fires tears which have a chance to freeze or petrify enemies, Counts as 1 of 3 familiar items needed towards the Conjoined transformation, When used, rerolls all items in the room into another random item from the current room's item pool, however the item also has a 30% chance to disappear, The chance associated with this item does NOT scale with your Luck stat - it's always 30%, In the game files this item is called 'Florians Dice', which is a reference to the Eternal update for the original Binding of Isaac game, which changed the D6 to act as this item does. REPENTANCE - The Nail's temporary damage bonus has been increased, and is now able to stack with itself. Blood Donation machines, UNLOCK: Unlock this item by beating the Isaac boss with The Lost, * item room, treasure room, item room pool, red, isaacs heart, A familiar ghost that follows Isaac around and chases enemies close-by, damaging them for 2 contact damage and causing a fear effect, * item room, treasure room, item room pool, white, lil' haunt, A familiar beggar similar to Bum Friend that follows Isaac and collects red hearts, giving Isaac black hearts, pills, cards, runes or spiders in return, For every 1.5 red hearts he takes, he will give a reward, Reward chances: Black Heart - 40%, Card/Rune - 20%, Pill - 20%, Blue Spider - 10%, Spider 10%, Item Pool: Item Room, Devil Room, Demon Beggar, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, celebrate good times come on, the lost item pool, qt 3.14, dark bum, otp, damn it reddit, horns, grey, gray, smile, A very large orbital that moves around Isaac very slowly, blocking shots and dealing 2 contact damage per tick, Affects the speed of all other orbitals, slowing them down a lot (NOTE: This effect does not happen until you get a new orbital after Big Fan), Does not count as one of your three standard orbital slots, * item room, treasure room, item room pool, fat, brown, An adorable friendly blue spider that walks around the room laying other blue spiders which attack enemies, She can only spawn a maximum of up to 5 spiders at a time and will only do so while there are enemies in the room, REPENTANCE - Sissy Longlegs now charms enemies upon contact, * item room, treasure room, sissy longlegs item room pool, qt 3.14, dark bum, otp, damn it reddit, blue, derpface, Spawns a friendly Mulligan that walks around the room. Stealing an item has a chance to fail (a buzzer sound will play if it fails), Enemies: Attacks the enemy until either the ghost or the enemy dies, Doors: Opens the door, even if it is locked, Secret room entrances: Explodes and opens the entrance, Boss rush door: Will open the Boss Rush door from either side, allowing you get into and escape the Boss Rush, Slot machines, dead shopkeepers: Charges towards them and explodes them, Added as part of the Afterbirth+ Booster Pack #3. One exception to this is if you are playing as Lazarus or have Lazarus' Rags - you will respawn in the same room and get the kill, Plan C is 5 times rarer than other items in the same item pool, making it less likely to appear, UNLOCK: Unlock this item by defeating Greedier Mode with Lazarus, Item Pool: Shop, Devil Room, Curse Room, Red Chest, Demon Beggar, When used, the D1 duplicates 1 random pickup in the current room. Half hearts heal a whole heart and full hearts heal 2 red hearts, UNLOCK: Unlock this item by beating Boss Rush with Maggy, * item room, treasure room, item room pool, the lost item pool, pink, purple, candy, Each time you enter a new room, damage is negated for the first time you get hit, Can be used to go in and out of a Curse Room without taking damage. These only appear if not all runes have been unlocked yet. The Binding of Isaac: Repentance . Dinner = +0.5 tears, +0.2 shot speed. Damaging the aggressive Blood Puppy will eventually return it to its normal state. Function: Adds a pair of familiars to your sides that deals 0.375x your tear damage. While held there is a small chance when using a tarot card or pill that a copy of it will be dropped on the floor next to you, +0.2 Damage Up for each 'evil' item you have, Items classed as evil in this case are Black Candle, Ceremonial Robes, Abaddon, Goat Head, Match Book, Missing Page 2, Safety Pin, UNLOCK: Unlock this item by beating Greed Mode with Eve, Invincibility lasts longer after getting hit (Increased i-frames), This makes it possible to use the Blood Donation machine twice from one hit of damage, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Samson, *, bandana, sling, white, knot, blindfold, +15% chance to get a double item room to spawn on the next floor, If the effect activates, two items spawn in your item room, however only one can be taken (Same effect as the More Options item), The chance doubles to +30% with the effect from Mom's Box, Automatically opens all shop room doors for free, UNLOCK: Unlock this trinket by donating 666 coins to the Greed Donation Machine, UNLOCK: Keeper starts with this trinket after beating Satan with Keeper, Forces the Greed and Super Greed mini bosses to no longer appear in shops or secret rooms, Holding Rib of Greed increase your chance to receive coin drops, UNLOCK: Unlock this trinket by beating Ultra Greed with Keeper, Donating to a Donation Machine has a chance to heal Isaac for a full red heart or spawn a Beggar, UNLOCK: Unlock this item by beating The Lamb boss with Keeper, Destroying poops now gives you a blue fly, While held, you heal for half a red heart every time you use a key to open a door or golden chest, Changes all half red hearts into full hearts, Hearts dropped from Tainted Magdalene's mechanic will be always full red hearts, *, red, brown, grey, gray, necklace, moms locket, mom locket, While this trinket is held you have a significantly lower chance to find spacebar/active items, It will cause passive items to spawn except when the game cannot generate any more passive items and will then instead choose spacebar/active items, Some hard coded spacebar items from bosses and mini-bosses (i.e. Broken hearts permanently subtract from your total possible health containers, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Magdalene, Isaac turns to stone and can't move for 10 seconds, but your tear rate goes up significantly for the duration, UNLOCK: Unlock this card by defeating challenge #42 (Hot Potato), UNLOCK: Unlock this card by defeating challenge #43 (Cantripped), "May you see the value of all things in life", When used, all items and pickups in the current room are turned into money. Doors remain open when entering a room with enemies in it. The Planetarium is a type of room that is featured in The. Counts as 1 of 3 poop items needed towards the Oh Crap transformation. in an Angel room, this will spawn 2 Angel room items), Starts with 0 charge and requires 12 charges to use, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Eden, Every 6-7 rooms Acid Baby will drop a random pill, Every time you use a pill, Acid Baby will deal 10 damage to all enemies and poison them for 6-7 ticks, REPENTANCE - Poison effect is stronger, but Acid Baby's pill drop rate has been reduced to every 6-7 rooms (previously every 2-3 rooms), A familiar fairy that will float around the room and highlight the location of any secret room doors, tinted rocks or trapdoors under rocks, Upon entering a new room, if there is an undiscovered secret room or tinted rock, it will move directly to the point of interest, otherwise it will just randomly fly around the room, For every empty red heart container, Isaac gains Damage Up and his body increases in size, Only works on full hearts - damage does not change if Isaac is missing 1/2 of a heart in one container, Healing empty red heart containers will remove the damage increases, Has no effect for The Lost and ?? Pretty Fly gives a Big Fan item rather than a fly orbital, UNLOCK: Unlock this by defeating Mega Satan as Tainted Eve, 1 Dot - Rerolls all of your items. Essentially you are rerolling all your items, but each new item you get to choose between 3 random options, The bedroom also contains a random trinket, 2 chests, 2 sacks and Isaac's bed, which can be used to full heal your red heart health, The only way to exit Isaac's bedroom is teleporting out or via the trapdoor, which takes you to the next floor. the lost item pool, white, blue, cross, jar, Gives Isaac an eternal heart and the ability to fly, UNLOCK: Unlock this item by beating the Chest with Blue Baby, * golden chest pool, gold chest pool, blue head, the lost item pool, dead, ball, Upon taking damage, Isaac will fart a few times, causing all enemies in close proximity to become poisoned and leaving a gas cloud behind, Black Bean deals your tear damage for 6 ticks, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, item room, treasure room, item room pool, the lost item pool, kidney, grey, gray, Allows Isaac to fly while the White Pony is held, While held, sets your speed stat to 1.5 if it isn't already that high. Kicking a frozen enemy will push it into the wall, where it shatters and fires ice shards everywhere (these can then freeze other enemies), Enemies touching the cube while it's not moving or moving slowly will become slowed for a few seconds, and take a small amount of damage, Cube Baby and enemies frozen will block enemy shots, Cube Baby can be launched across the room if you have a melee weapon, Enemies that die now spawn a red ghost, that floats in place of where the enemy died, Activating the item causes all red ghosts in the room to explode, dealing damage to any enemies near them, The explosion doesn't deal damage to Isaac, Damage dealt by each ghost is 3 + 0.04x the HP of the enemy it spawned from, Larger enemies such as minibosses will spawn a larger red ghost that causes 3 explosions, The red ghosts can be moved around slightly by firing tears through them, Using the item will instantly kill any enemy or boss that has the 'ghost' tag and is at 50% or less HP. Doing so will cause it to increase in size, and also increase their damage and the damage of the burst tears, Once a tear is fed 5 times, it will immediately burst, Tears in the burst will deal half the damage the main tear would have, Added as part of the Afterbirth+ Booster Pack #4. This is to prevent a syngery like Dr. Fetus or a Golden Bomb giving you infinite resources, Isaac's shadow will follow closely behind him and when it comes into contact with enemies, will spawn friendly dark charger mobs, The chargers deal contact damage to enemies, and will be killed if it is hurt too much, Chargers disappear upon entering a new room, UNLOCK: Unlock this item by beating Greed Mode with Judas, Every time you kill an enemy a fly will be added to the Jar, allowing you to stack up to 20, Using the Jar of Flies will release all the flies that are currently in the jar as friendly flies that will damage enemies, A Loki familiar that follows Isaac and shoots tears 4 tears in a cross pattern, dealing a flat 3.5 damage each, Gives Isaac a familiar glass of milk that follows him and spills on the floor upon taking damage, After being spilt, the milk gives you a -2 Tear Delay (Tears up) for the rest of the room, When used, the D7 will restart the current room and bring back all enemies once again, enabling you to farm rewards that spawn at the end after beating the room, Can be used to generate infinite consumable combinations, gaining as many coins/keys/bombs as you need, This item has no effect in Greed Mode, Challenge Rooms and rooms that had no enemies in originally, If used in a Boss Room or Angel/Devil Room, you get teleported to another random room, which is reset instead of the boss/angel/devil room you were in, Enemies respawned by the D7 don't drop loot if they were champions and also don't grant score in daily runs, * dice, pip, die, turban, white, grey, gray, Makes Isaac very small like a baby, reducing his hitbox size, When used, Mom's Box will drop a random trinket on the ground, While held, doubles the effect of trinkets which make sense to be doubled (e.g. ?, Satan and The Lamb as Tainted Jacob, Gives you a familiar that follows Isaac's exact movements (similar to how Jacob & Esau work) and shoots spectral tears, Similar to Jacob and Esau, positions can be altered by running it into objects, or holding the drop button (Ctrl on Steam version), When you place a bomb, the Found Soul will drop one too, If it takes any damage, it will die and not respawn until the next floor, UNLOCK: Unlock this trinket by defeating Mother as Tainted Jacob, Everytime you use your active item, you have a chance to activate another random active item, Glowing Hourglass effect is blocked from this item, UNLOCK: Unlock this trinket by defeating Isaac, ?? purple, pink, mask, face, Puts a shield in front of Isaac which blocks projectiles, The shield will rotate based on the direction in which Isaac is firing tears, * angel room pool, god room pool, angel room item, blue, silver, metal, Gives Isaac a laser that will fire at random intervals in addition to your normal tears, Each laser does damage equal to your current tear damage, The laser will occasionally fire with one of these effects: Hook Worm, Spoon Bender, Tiny Planet, Mysterious Liquid, Rubber Cement, Luck has no effect on the rate at which Tech.5 fires and does not scale with items that increase your tears stat, UNLOCK: Unlock this item by beating Challenge #18 (The Host), * technology.5, tech 5, item room, treasure room, item room pool, white, red, eye, robot, Isaac now shoots two tears at once, but dealing -20% damage each, Unlike the Inner Eye and Mutant Spider items, this double shot item does not give a tears down, * 20 20, 2020, item room, treasure room, item room pool, black glasses, spectacles, Reveals the locations of the secret and super secret room for the current floor and all future floors, UNLOCK: Unlock this item by donating 10 pennies to the Shop, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, This may cause you to skip floors where you left a trinket to spawn a Cracked Key. Creator Edmund McMillen called it the "best version of Isaac". I would understand if they would tune down normal mode tho, but leaving hard mode as it is presents a nice option for people who want a challenge. It gives you 2 seconds to pick it up again to re-heal, before it disappears, UNLOCK: Unlock this item by defeating Delirium as Tainted Magdalene, Whenever you deal damage to an enemy, has a chance to give the effect of one of Tainted ??? Find it . Now grants a half black heart upon use instead of a full soul heart. ?, Satan and The Lamb as Tainted Judas, Changes Devil Room layouts. This doesn't convert hearts that dropped before picking up this trinket, and doesn't apply to set heart drops, i.e. Each use also gives +0.5 Black Hearts, however this is stays between rooms unlike the other effects, Allows Isaac to deal 40 contact damage to enemies for the current room. Holding down the fire button again will quickly release all stored teared, The charge time and max tears stored scales with your current tears stat, Greatly reduce Isaac's size, to an extent where some enemy tears will now travel straight over him without dealing damage if they are high off the ground. Deals 45 damage to enemies it lands on. Can be negated with Black Candle, Bad Gas - Isaac farts, poisoning enemies around him, Bombs are key - Switches number of bombs and keys, Explosive Diarrhea - Spawns five live troll bombs behind Isaac, one per second, Full Health - Restores all your empty red heart containers, Health Down - -1 HP. as Bethany, Gives you a random syringe effect every room, The effect can be The Virus, Roid Rage, Speed Ball, Experimental Treatment, Synthoil, Euthanasia or Growth Hormones, Placed bombs explode after 0.66 seconds instead of the usual 1.5 seconds, This was called Exploded Firecracker in Antibirth, Farts produced by Isaac or familiars will be twice as large, Chance for enemies to burn when entering a room, The chance for this effect to activate is effected by your Luck stat, This includes key blocks and golden chests, Pickups left on current floor will appear in the starting room of the next floor, up to a maximum of 4 pickups, Active items will be rerolled upon using them, Using with Book of Virtues will only reroll the item the book is holding, Has no effect with Notched Axe due to how its durability works, UNLOCK: Unlock this trinket by defeating Mother as Eden, Random luck-based tear effects have an extra chance of occurring, The additional chance is effectively +3 Luck Up, Picking up red hearts now has a high chance to spawn 1-4 blue attack spiders, instead of giving you health back, This effect also works while fully healed, giving a guaranteed chance of getting spiders, While missing any red health the chance for spiders is less, Works for characters that don't use red health, which always gives you spiders, Hearts in Shops can be converted into spiders for free, Gives your familiars improved rate of fire while held, In Antibirth this trinket was called Song of the Siren, UNLOCK: Unlock this trinket by bombing the skull left by The Siren boss after her death, While held at the start of each floor, this trinket spawns four wisp familiar orbitals around Isaac, These wisps are the same as the ones created by the Book of Virtues item, UNLOCK: Unlock this trinket by beating the Boss Rush as Bethany, Your active item no longer gains charges, but battery drops become much more common, UNLOCK: Unlock this trinket by blowing up 10 Battery Beggars, Tears that miss enemies will redirect themselves and travel 90 degrees towards enemies, Tears must be roughly 2 tiles or closer to activate this effect, +10 Luck while held, but the trinket is destroyed when damage is taken, Blood donation machines, Curse Rooms and Sacrifice Rooms wont destroy it, Taking a hit and activating Holy Mantle won't destroy it, Can be dropped in order to avoid breaking it, This trinket is automatically given to you after clearing 3 bosses without taking damage, Treasure Rooms are replaced with Red Treasure Rooms, which contain a deal with the devil in place of a regular item pedestal, If an item room has not yet been entered, it can be transformed to either a regular or Red Treasure Room by picking up or dropping this trinket before entering, Does not affect the mirrored treasure room in Downpour II, UNLOCK: Unlock this trinket by defeating Mother as Azazel, Every time you pick up a coin, you have a small chance to gain 1 bar of charge on your active item, The chance for this effect to happen is 1/6th of the value of the coin picked up, Can only activate once per coin collected, In Antibirth this trinket was called Electric Penny, UNLOCK: Unlock this trinket by donating to a battery beggar until he pays out with an item 5 times, While held, your familiars will now orbit around Isaac instead of following behind him, Activates your active item just before damage would be taken, It doesn't activate for free - the charges are used up as normal if this effect activates. 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